60-day full refund
7 verified stories
The plant 7 people used to silence their inflammation.
Cat’s Claw extract from the Peruvian Amazon. Real names, real numbers, real before-and-afters. We’ll email you when our first batch ships.
Three things get measurably better.
Cat’s Claw doesn’t promise miracles. It does three things consistently across our 7 verified outcomes.
Inflammation goes down
Joints, gut, CRP markers. James’s CRP dropped from 8.2 to 2.1. Linda’s morning stiffness disappeared. Numbers, not vibes.
Energy comes back
Post-viral fatigue, brain fog, afternoon crashes. Marcus’s nap habit gone in 12 weeks. Back to weekend hikes.
Immune system rebalances
Autoimmune flares calm. Recovery accelerates. Janet’s UC in remission for the first time in 9 years.
“My CRP had been climbing for three years — 8.2 at the worst. Three months in, it was 2.1. My doctor asked what I was doing differently. I sent her the bottle.”
Systemic inflammation · Denver, CO · Verified
Different conditions. Same plant.
Every story below comes from a verified customer who shared their full name, condition, and measurable result. Swipe through.
“Six months ago, thirty minutes of gardening meant ibuprofen and an ice pack that evening. Eight weeks into the protocol, I can go two hours straight.”
“Last fall I was napping every afternoon. Twelve weeks on the extract, I’m back to full days and weekend trail runs.”
“For two years my CRP wouldn’t budge below 6.5. Three months in, my rheumatologist saw the lowest markers since I was diagnosed.”
“Twenty-three years of IBS, gone in fourteen weeks. I keep waiting for the relapse. It hasn’t come.”
“For years I avoided the stairs in our house. Eight weeks in, I’m taking them without thinking about it. Cooking again. Even moved the rug back.”
“My CRP had been climbing for three years — 8.2 at the worst. Three months in, it was 2.1. I sent my doctor the bottle.”
“Nine years of flares. Four months in alongside my mesalamine, I’m in the longest remission I’ve ever had. This changed what I can do with my meds.”
7 verified stories
Is Cat’s Claw for you?
We don’t want returns. We want fit. Here’s the honest answer of who this helps and who should skip it.
Cat’s Claw might help if you’re managing
- Joint pain or arthritis (osteo or rheumatoid)
- Chronic inflammation (high CRP, persistent fatigue)
- Leaky gut, IBS, or IBD (as adjunct, not replacement)
- Post-viral recovery (long COVID, EBV, persistent fatigue)
- Lyme & tick-borne illness (alongside your protocol)
- Autoimmune conditions where immune modulation is the goal
Cat’s Claw is NOT for you if
- You’re pregnant, planning, or breastfeeding
- You’re on anticoagulants (warfarin, aspirin)
- You’re on immunosuppressants (cyclosporine, tacrolimus)
- You’re under 18
- You’ve had a transplant or are immunocompromised
- You’re expecting it to replace prescription medication
2,000 years of use. 200+ studies. One plant.
Cat’s Claw (Uncaria tomentosa) is a vine from the Peruvian Amazon. The Ashaninka have used it for two thousand years. Modern science has now indexed more than 200 peer-reviewed papers on it.
What matters about ours, in plain English:
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3% POAs, TOA-free
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The chemistry that actually works. Many cheap brands include the chemistry that opposes it. -
Liquid extract, sublingual
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Drops under the tongue. Higher absorption than capsules. -
Made to GMP standards
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Same manufacturing quality controls as pharmaceuticals. -
Peruvian-sourced
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From where the plant actually grows. Not blended with cheap fillers.
Get on the list. Get the first batch.
We’re a small operation. Our first batch is in production. We’ll email you when it ships. We won’t charge a thing until you confirm.
One email when the batch ships. No spam. Unsubscribe anytime.
60-day full refund
If your first bottle isn’t what you expected, send it back within 60 days — even half-used — full refund.
Free US return shipping
We pay the return shipping label. No hidden fees, no restocking charges.
No charge until shipping
You won’t be billed when you join the list. We confirm with you when the batch is ready.
We’re small, but the manufacturing is serious.
Ground Rise is a new brand. Our first batch of Cat’s Claw extract is in production. The bark comes from the Peruvian Amazon; the laboratory that produces our extract holds GMP and HACCP certifications, and each batch is formulated to be Paleo-friendly, vegan, and gluten-free. What we don’t have yet is a long client roster or a glossy founder story — what we have is the plant, the lab standards below, and a 60-day refund window.
What is Cat’s Claw?
Cat’s Claw is a woody vine of the Rubiaceae family. Its botanical name is Uncaria tomentosa; in Spanish it is called uña de gato. The plant grows in a thin band of cloud forest on the eastern slopes of the Peruvian Andes, where it uses hooked thorns — the “claws” the supplement is named after — to climb cecropia trees fifty meters into the canopy in search of light.
There is one fact about Cat’s Claw that most supplement brands skip, and it determines whether the extract you take will do anything at all: the plant has two distinct chemotypes — and only one is medicinal. The pentacyclic oxindole alkaloid (POA) chemotype is the one with two thousand years of traditional use and the bulk of modern research behind it. The tetracyclic (TOA) chemotype actually opposes the immune-modulating effects of POAs, which is why source and standardization matter more for Cat’s Claw than for almost any other herbal supplement on the market.
Ground Rise Cat’s Claw extract is manufacturer-tested to be POA-dominant (standardized to ≥3% by mass), TOA-free. Single cooperative, single valley, single harvest window. The kind of provenance you can trace on a map.
TOA-free
3% standardization
Single-origin Peruvian
Manufacturer-tested
Where Cat’s Claw comes from: Peruvian-sourced Amazon
Madre de Dios is the last department of Peru before the Brazilian border. It is also the most biodiverse stretch of the western Amazon — and the only place in the world where Cat’s Claw grows wild with verified POA-dominant chemistry. We work with sourcing partners in the Peruvian Amazon has been harvesting Uncaria tomentosa under government permit today — only the outer bark, only from mature vines, never killing the plant.
Our sourcing prioritizes botanical-grade material harvested by experienced gatherers. Our goal is to publish detailed traceability documentation as the brand grows. This is not the “wild Amazonian” marketing language that most Cat’s Claw supplement brands use. This is one valley, and documented sourcing practices we share with customers as we scale.
How Cat’s Claw works: the science of Uncaria tomentosa
Cat’s Claw’s medicinal action is concentrated in six pentacyclic oxindole alkaloids — isopteropodine, pteropodine, mitraphylline, isomitraphylline, uncarine F, and speciophylline — plus a family of quinovic acid glycosides and antioxidant procyanidins. More than 200 peer-reviewed papers on Cat’s Claw are indexed on PubMed since 1985.
In the body, these alkaloids do three things consistently across published trials: they modulate the immune system (rather than just suppress or stimulate it), they reduce NF-κB-driven inflammation, and they support DNA repair pathways in cells under oxidative stress.
“Modulate” is the operative verb. The plant doesn’t push the immune system up or down — it pushes it toward the right response for the situation. That is why the same extract is studied for both autoimmune flare-ups (calming) and post-viral fatigue (activating).
— Selected references: PubMed, “Uncaria tomentosa”, 1985–2025. Ask us for the full bibliography.
Six Cat’s Claw protocols by condition
Cat’s Claw is not a cure for any of these conditions. It is an evidence-backed adjunct that, when paired with the right diet, sleep, and movement, has improved outcomes for thousands of people. Pick the Cat’s Claw protocol closest to what you’re working with.
Cat’s Claw for joint pain & arthritis
A protocol for rheumatoid arthritis, osteoarthritis, and chronic joint stiffness. Best paired with omega-3 and an anti-inflammatory diet.
Read the Cat’s Claw joint pain protocol →
Cat’s Claw for leaky gut & intestinal inflammation
A protocol for restoring tight-junction integrity in the small intestine. Use alongside L-glutamine and a 30-day food trial.
Read the Cat’s Claw leaky gut protocol →
Cat’s Claw for post-viral immune recovery
A protocol for long COVID, post-EBV fatigue, and persistent inflammation after acute infection. Stack with NAC and quercetin.
Read the Cat’s Claw immune recovery protocol →
Cat’s Claw for chronic systemic inflammation
A protocol for elevated CRP, persistent fatigue, and metabolic markers off-baseline. Combines with curcumin and dietary work.
Read the Cat’s Claw inflammation protocol →
Cat’s Claw for Lyme & tick-borne illness
A Cat’s Claw protocol as adjunct to standard treatment for Lyme, Bartonella, and Babesia. Cowden and Buhner approaches compared.
Read the Cat’s Claw Lyme protocol →
Cat’s Claw for IBS & IBD support
A protocol for Crohn’s, ulcerative colitis, and IBS-mixed. Coordinate with your GI — Cat’s Claw doesn’t replace mesalamine or biologics.
Read the Cat’s Claw IBS & IBD protocol →
Five companion practices that amplify Cat’s Claw
Cat’s Claw works best when the rest of the terrain is on its side. These five practices each have independent evidence — and each multiplies what the Uncaria tomentosa extract can do for you.
Anti-sugar reset
21-day glucose stabilization plan. Removes the single biggest driver of the background inflammation Cat’s Claw is fighting.
Start the 21-day plan →
Anti-inflammatory diet
Mediterranean baseline + autoimmune adjustments. Full food list and 14 recipes that pair with any protocol.
Get the food list →
Meditation & immunity
Three studies, three practices. Twenty minutes a day measurably lowers IL-6.
Start the practice →
Sleep architecture
Deep-sleep and REM optimization. Where tissue repair actually happens — the extract can only do so much without it.
Fix your sleep →
Intermittent fasting
16:8 and 18:6 schedules. Autophagy timing improves alkaloid absorption.
Time your eating →
Cat’s Claw dosage and how to use it
The condition-specific Cat’s Claw protocols above give exact dosing. These three principles apply to all of them — and to any Cat’s Claw extract or supplement you use, not only Ground Rise.
Take it on an empty stomach
Twenty minutes before food, twice daily. The alkaloids absorb better without food competing for transport. Coffee or water — both fine.
Cycle your dosage
Most protocols recommend 6–8 weeks on, then 2 weeks off. The immune-modulating effect benefits from rest periods. Continuous use beyond 12 weeks without a break is rarely necessary.
Pair the extract with sleep
The anti-inflammatory effect roughly doubles when sleep is in the 7–9h range. The plant does its work; sleep does the rest. Not optional.